Bioactive substance polyoxypeptin and deoxypolyoxyppeptin and anticancer drug containing the same

摘要

As a new substance with apoptosis inducing activity against cancer cells, the following general formula (I)(in the equation, R shows hydroxyl groups in polyoxypeptidines and R shows hydrogen atoms in deoxypolyoxepipine), and the polypoietin and deoxypolyoxypeptin expressed by Streptomyces ESP mk498-98 Four strains were obtained by culture. Polyoxyppeptin and deoxypolyoxyppeptin are bioactive substances that activate apoptosis in human pancreatic cancer cells and appc-1 cells.