Thiazolidinedione Derivatives, oxazolidindiona and oxadiazolidindiona, Process for their preparation, Pharmaceutical compositions and formulations.Use of these compounds for the manufacture of formulations and method of Treatment

摘要

The dissolved salts and hydrates with general formula I, stereoisomers, optical isomers and racemates, and acceptable to the same pharmacist, which are produced from thiazolidine, oxazolidinia and oxazolidinia derivatives. In these substances, the dial line is a simple or double line, R is h oalquilo, a is s, O NH, B is C, ch or N, D is At orthogonal position, target or stop,And represents cn-x-y-z, D in orthogonal position, target or is, and represents h-o-tar, tar, halogen o-x-y-z, where x is O, N1, SO2 or s, R1 is h or tar, and is SO2, Co, or chemical bond, Z esalquilo, tar replaced by one or more chlorine fluoride atoms, arilo, alternative arilo, rental, or2 or NH3. R2 means any one or more perfluorooctane sulfonic acid or chlorine substituted tar, arilo, substituted arilo or tar, R3 is h, asphalt, arilo leased, substituted arilo or substituted tar, provided that x is or onr1, or SO2 or Co, and Z is (a) SO2, or (a) SO2,Arilo, arilo replacement and rental, provided y is (b) Co, selected from or2 and NHR3 groups, where R2 and R3 were previously sedefinen, while X was SO2, then a link between chemicals and Z, selected from the asphalt group, replaced by a fluorinated or chlorine atom asphalt, replaced by arilo, Let it and or2, in which R2 is defined above, when x is s, then it is a chemical tank and Z is selected from a group of tar, and replace the tar with one or more fluorine or chlorine atoms, arilo, arilo, arilo, and if B is n, a is O, the preparation process,Compounds and agents containing these substances