A formulation that allows the stabilization of Aqueous Peg interferon alpha Conjugates during and after the freeze-drying process to produce a Powder, a Powder,A process for producing a solution of conjudados Peg interferon alpha and an article of manufacture

摘要

Aqueous formulations comprising conjugated Peg interferon alpha, a buffer, a Stabilizer, a process deliofilizacion cryoprotectant, and a Solvent;A Dust biofilizado and an article of manufacture.These formulations previenenla Loss and Damage (PEG interferonalfa during and after lyophilization; protect the peg interferon alpha Conjugates against Loss and DegraDuring the process deliofilizacion dation.As well as against ladegradacio during subsequent Storage and are suitable for the Protection of conjungados Peg interferon alpha against various types of degradation, including,But not limited to, the loss of Biological activity ycambios gra in the OJ and / onaturaleza of Conjugation.A conjugated Peg interferonalfa Preferred can be protected in these formulations is a Conjugate of interferon alfa - 2b - polyethylene glycol (12000).