An acid derivative 2-methylpropionate, a Pharmaceutical composition that includesUse of a 2-methylpropionate acid derivative and a process for the manufacture of a Pharmaceutical composition for the Prevention or treatment of diseases

摘要

The 2-methylpropionate acid derivative represented by the General formula (i), wherein R1 represents a group of HydroxyA aralquilo Lower alkoxy group or Group; R2 represents a group of HydroxyA Lower alkyl group, or a Halogen Atom; a represents an oxygen Atom or an imino Group; The u00e1tomode C (R) is marked with a C Atom in the R configuration and the C Atom MarkOr (S) represents a C Atom in the configuration s and its salesfarmacu00e9uticamente acceptable;They have excellent effects of beta3 adrenoceptor stimulants and are useful as agents for the Prevention or treatment of Obesity, hyperglycemia,Diseases caused by intestinal hypomotility, pollakiuria, urinary incontinence,Indepression or Diseases caused by gallstones or hypomotility of the biliary Tract. Pharmaceutical composition comprising Said derivadocomo Agent and active component.A procedure for the manufacture of a Pharmaceutical composition that uses the derivative as Essential constituent.