Indolinonas replaced and their physiologically compatible salts, a process for their preparation, their use for Preparation of Drugs,Medicines containing them and Process for the preparation of these medicines

摘要

Indolinonas replaced by general formula (I), where X represents oxygen or sulfur atom; R1 represents hydrogen atom, a group of alcoxc1-4-carbides or c2-4 alkanes; R2 represents a group of carboxi, alcoxi c1-4-carbonated oaminocarbon, in which part of ammonia water can be replaced by one or two groups of c1-3 coke oil; and Substitutes may be the same or different; R3 refers to a phenyl or Nagorno substance, which can be substituted by PVC c1-3, alcox c1-3, cyanogen, trifluoroethane, nitric acid, aminobenzene, c1-3-aminostone, di - (c1-3-tar) - amino, alkane-2-4-amino, N - (c1-3-tar) - alkane c2-4-amin for the monoatom of fluorine and chloroobromo,C1-3alkyl-sulfonylamino, amino-C1-3alkyl, C1-3alkyl-amino-C1-3alkyl, d i- (C1-3alkyl) -amino-C1-3alkyl, N- (C2-4alkanoyl) -amino-C1-3alkyl or N- (C2-4alkanoyl) -C1-3alkyl-amino-C1-3alkyl, and the substituents may be the same or different; R4 means a hydrogen atom or a C1-3 alkyl group; and R5 signifies a hydrogen atom, a C1-5 alkyl group optionally substituted with a group, phenyl, carboxy or C1-3 alkoxycarbonyl, a C3-7 cycloalkyl group optionally substituted with a C1-3 alkyl group, an indalyl group eventually substituted with a C1-3 alkyl group,An abiotic group consisting of five members, including one ultimately composed of c1-3 tar, oxygen or sulfur atom, one ultimately substituted by c1-3 tar and one carbon atom, sulfur or nitrogen atom or two denitrogeno atoms, or one composed of six members consisting of one to three atoms. Nirogeno,In addition, a 1.3-butadiene bridge can be added, passing through two adjacent Dec atoms, or through the C atom and the adjoining imino group of the heteromorphic group of the above 5-6 members. The single and double ring carbide skeletons may be single. Hydrofluorocarbons containing fluorine, chlorine, bromine or iodine atoms, C1-5 tar group or cyanogen group and substitutes may be the same or different; a group of pyridine or pyridinediol passes through