首页> 外国专利> A polymorphic Form 1 (-) - 4 - 4 - 4 - (2R CIS - 5 - (2 - difluorfenil tetrahydro - 5 - (1H) - 1,2,4-triazole - 1 - methyl - 3 - il) furan methoxy phenyl - 1-piperazinyl phenyl - 2,Dihydro - 4 - 2 - (S) - 1 - (S) - ethyl - 2 - hydroxypropyl - 1,2,4-triazole - 3H - 3-one, Pharmaceutical composition containing it and its use in preparing a Medic

A polymorphic Form 1 (-) - 4 - 4 - 4 - (2R CIS - 5 - (2 - difluorfenil tetrahydro - 5 - (1H) - 1,2,4-triazole - 1 - methyl - 3 - il) furan methoxy phenyl - 1-piperazinyl phenyl - 2,Dihydro - 4 - 2 - (S) - 1 - (S) - ethyl - 2 - hydroxypropyl - 1,2,4-triazole - 3H - 3-one, Pharmaceutical composition containing it and its use in preparing a Medic

机译:多晶型物1(-)-4-[4-[[4-[[((2R CIS)]-5-(2--四氟联苯四氢-5-(1H)-1,2,4-三唑-1-甲基- 3-il)呋喃] [甲氧基]苯基]-1-哌嗪基苯基-2],二氢-4-2--[(S)-1-(S)-乙基-2-羟丙基-1,2,4-三唑- [3H]-3-one,包含它的药物组合物及其在制备Medic中的用途

摘要

(1-trimethyl-methyl-polychlorinated dibenzo compounds, 1-trimethyl (1) benzo-trimethyl-methyl-or crystals in the next diffusion window a. X-ray dust, expressed by entertainment D and relative intensity (IR): spacing D (+; - 0.04) IR; average 6.10; average 4.63; width 3.69;3.05 contains this polymorphic substance and a wide range of pharmaceutical ingredients in cosmetics for the treatment of fungal infections in mammals. 4 - [4 - [4 - [(2r-cis) - 5 - (2,4-difluorophenyl) tetrahydro-5 - (1h-1,2,4-sulfur trifluoride)-1-methyl (furan-3-il) methoxy] - 1-pipeerazinil] phenyl-2,4-dihydro-2 - [(s) - 1-ethyl-2 (s) - hydroxypropyl] - 3h-1,2,4-triazol-3-ona is an antifungal drug, which has the following advantages compared with the non patented form of the former technology: low impurity content, stable product qualityIn other words, the physical properties, including color and speed, are more stable, easier to operate and have a longer stability period.
机译:(1-三甲基甲基多氯代二苯并化合物,1-三甲基(1)苯并三甲基甲基或晶体在下一个扩散窗口中a。X射线尘埃,用娱乐性D和相对强度(IR)表示:间距D (+;-0.04)IR;平均6.10;平均4.63;宽度3.69; 3.05包含这种多态性物质和化妆品中用于治疗哺乳动物真菌感染的多种药物成分4-[4-[4-[( 2r-顺式)-5-(2,4-二氟苯基)四氢-5-(1h-1,2,4-三氟化硫)-1-甲基(呋喃-3-il)甲氧基]-1-哌嗪腈]苯基- 2,4-二氢-2-[[s]-1-乙基-2(s)-羟丙基]-3h-1,2,4-三唑-3-ona是一种抗真菌药物,与以下药物相比具有以下优点前一种技术的非专利形式:杂质含量低,产品质量稳定换句话说,包括颜色和速度在内的物理性能更稳定,更易于操作且具有更长的稳定期。

著录项

  • 公开/公告号AR015947A1

    专利类型

  • 公开/公告日2001-05-30

    原文格式PDF

  • 申请/专利权人 SCHERING CORPORATION;

    申请/专利号AR1998P104957

  • 发明设计人

    申请日1998-10-05

  • 分类号C07D405/14;A61K31/495;A61K31/34;A61K31/41;A61P31/10;

  • 国家 AR

  • 入库时间 2022-08-22 01:26:19

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