Certain 1 - (2 - azanaftil) - 4 - (1) - phenylmethyl) Piperazines, ligands of specific subtypes of dopamine Receptors

摘要

A compound comprising a formulated or pharmaceutically acceptable addictive salt, wherein X, y and Z are equal to or different from CRC or nitrogen; RC represents hydrogen, halogen or C1-6 tar; R1 and R2 represent independent hydrogen, halogen, hydrogen Xi, C1-6 tar, trifluoromethyl, trifluoroaiodofluoromethane or so2nh2, If the CH, R3 and R4 represented by Y and Z in both cases are hydrogen, R1 and R2 are not the same hydrogen; or R1 and R2 together represent a C1-2 tar group or c1-3 tar group; R3 and R4 are the same or different, and represent nhydrogeno, halogeno, C1-6 tar, alcox C1-4, asphalt, hydroxi, amine,1. Single machine or diallamino containing C1-6 pitch, cyanogen or other Perfluoromethyl alkyl; arepresente C1-4 pitch; and R5, R6 and R7 are independent C1-6 hydrocarbon or hydrocarbon; Selectively related to the D4 distribution pairs of dopamine receptors, it can be used to treat and / or suppress various neuropsychological or emotional disorders, including schizophrenia, manic, dementia, depression, anxiety, compulsive behavior, and drug abuse, Memory impairment, blood loss, Parkinson's engine disorderFor example, Parkinson's disease, paranoia and motor disorders related to the use of neurophotics, these compounds can be used to treat depression, memory failure or Alzheimer's disease through the D4 receptor module selectively present in the libika area, We know it controls emotional and cognitive functions In addition, these calculations are useful for the treatment of other diseases caused by dopamine blockade,For example, drug abuse and obsessive-compulsive mental disorders. These compounds can also be used to deal with spillover effects associated with the use of conventional neuro optical agents.