首页>
外国专利>
Method for preparing 3 - (4 - 2 - (n-methyl-n - (2-pyridyl) amino) ethoxy benzyl} - 2.4 - Thiazolidinedione, or one of its forms tautomericas or its Salts
Method for preparing 3 - (4 - 2 - (n-methyl-n - (2-pyridyl) amino) ethoxy benzyl} - 2.4 - Thiazolidinedione, or one of its forms tautomericas or its Salts
A procedure for the preparation of 5 - [4 - [2 - (n-methyl-n - (2-pyridyl) amino) ethoxy] benzylidene] - 2.4 - Thiazolidinedione, or one of its forms tautomeras, or of one of its sussales or solvates,Characterized in that it comprises a reducing Compound whose Catalytic Reduction reaction is performed using a hydrogen pressure exceeding 1.4 kg / cm2 (20 psi); and then, if desired,Form a pharmaceutically acceptable Salt or solvate and a pharmaceutically aceptabledel Compound of formula I: where A1 is 2 - piridilo; r1 is Methyl; and N is 1 and A2 is P - phenylene,For prophylaxis and / or treatment of Type II dediabetes and hyperglycemia.
展开▼
机译:制备5- [4- [2-(n-甲基-n-(2-吡啶基)氨基)乙氧基]亚苄基] -2.4-噻唑烷二酮或其互变异构体形式之一或其中之一的制备方法其特征在于它包含一种还原性化合物,其催化还原反应是使用超过1.4kg / cm 2(20psi)的氢气压力进行的;然后,如果需要,形成式I的药学上可接受的盐或溶剂化物和药学上可接受的化合物:其中A1为2-哌啶子基; r1是甲基; N为1,A2为对亚苯基,用于预防和/或治疗II型糖尿病和高血糖症。
展开▼