Pharmaceutical dosage form entericamente coated extended release of an inhibitor of H +, K + - ATPase, Process for its manufactureUse of pharmaceutical dosage form of the inhibitor and use for preparing Medicine

摘要

A long-term anesthetic release drug dose of H +, K + - atpas inhibitors, which provides long-term plasma separation of H +, K + - atpas inhibitors. The long-term characteristics in plasma are obtained by a drug synthesis method, including a kind of nucleon material in the water bottom or hydrofluorocarbon matrix, H +, K + - atpas inhibitors and optional drug front agents. H +, K + - atpas inhibitor is a formulated compound (I),Het1 is a formula (II);Het2 is formula (III);X = formula (IV),In reaction benzimidazol, n means that one of the cyclic carbon atoms substituted by r6-r9 can selectively exchange the denitorogeno atom without any substitutes; R1 R2 and R3 are the same or different, and are selected from hydrogen, tar and alcoxi, and can be replaced by fluorination, tar and alcoxix, Dichloromethane, pyridinediol, morphine, hydrogen halide, phenyl and phenylethanol; R4 and R5 are the same or different, and dehydrogenation, alkylation and arilalquilo are selected; R6 is hydrogen, halogenation, trifluoromethyl, tar or alcox; R6 and R9 are the same or different, and dehydrogeno, alcox, halogeno, halogeno, alcox, acarbonil are selected,Carbon oxide, oxazolinilo and trifluoroalkyl, or adjacent r6-r9 groups form deanillo structure which can be further replaced; R10 is a hydrogen structure, or forms an asphalt chain together with R3, R11 and R12; or different gypsum selected from hydrogen, halogenated hydrogen or aspha or an alkaline salt selected from it, One of its dwarfs or one of its alkali salts. It is better to select H +, K + - atpas inhibitors from the omeprazol group, omeprazol basic salts, deomprazal counterparts or (-) omeprazol counterparts or groups composed of lanzoprazol and pantoprazol.Alkaline salt, dwarfism, or alkaline salt. The underwater matrix is a kind of underwater polymer or a mixture of underwater polymers. Bottom matrix