Use of an FPT inhibitor and an antineoplastic Agent in the preparation of a drug For Combination Therapy

摘要

Use an FPT inhibitor to prepare a compound therapy including an effective amount of (1) an FPT inhibitor and (2) an antineoplastic agent and / or radiation therapy to treat patients in need of such treatment, and explain when the inhibitor FPT is a compound with a formula in which the dotted line represents an optional double link, X is a hydrogen halide, and is hydrogen, coor is a C1-12 tar or alternative tar, phenyl, alternative phenyl, rental c7-12 or alternative arilalquilo, 2 -.3...Or 4-piperizilo or piperizilo n-replaced, where the alternative to C1-12 is selected from the pitch of C1-6, Choose the halogen and halogen substitutes in C1-6 tar and C1-6 tar, choose C1-6 from C1-12, phenyl, phenyl substitutes, arilalquilo c7-12, choose 1-4 or so2r1 from C1-6 tar and halogenated tar as C1-12, phenyl, phenyl substitutes, arilalquilo c7-12; Then the chemotherapeutic agent was not selected as a group of substances including vinca alkaloid, epipodofilo toxin, anthrax antibiotic, actinomicina D, pliamicina, puromicina D, gramicidina D,taxol colquicina citocalasina B emetina maytansina amsacarina Seproveen usos para preparar medicamentos para tratar enfermedadesproliferativas especialmente c nceres qu e comprende (I) un inhibidor de la trasnferasa deprote na farmesilo conjuntamente con (2) un agente antineopl sico y 2Fo terapia de radiacion