首页> 外国专利> A variable region of light chain and a heavy chain, Nucleic Acid molecules that ENCODE, Expression Vectors, Chimeric Antibodies that bind to human CD40,Humanized Antibodies and Pharmaceutical compositions comprising such Chains.

A variable region of light chain and a heavy chain, Nucleic Acid molecules that ENCODE, Expression Vectors, Chimeric Antibodies that bind to human CD40,Humanized Antibodies and Pharmaceutical compositions comprising such Chains.

机译:轻链和重链的可变区,编码的核酸分子,表达载体,与人CD40结合的嵌合抗体,人源化抗体和包含此类链的药物组合物。

摘要

Applicants found new anti-human chemical and humanitarian antibodies to the CD40, blocking the interaction between gp39 and CD40. CD40 antibody is effective for T cell antigens, Copernicus induced arthritis, and skin allogeneic humoral immune response modules, and also for its anti-inflammatory properties. These chemical antibodies include: (a) a light chain consisting of all or part of the AC bioionosphere of the synthetic amino acid sequence and shown in ID NS1 (Figure 4a).O (b) as shown in ID ns: 2 (Fig. 4b), a heavy chain composed of all or part of the bioactive components of amino acid sequence;o (c) amba s (a) y (b) Adem sse revelan las mol culas que codifican las cadenas largas ligeras y pesadas de los anticuerpos quim ricos los vectores de expresion correspondientes losanticuerpos humanizados y las composicionesfarmac uticas que contienen dicho s anticuerpos y quim
机译:申请人发现了针对CD40的新的抗人类化学和人道主义抗体,从而阻断了gp39和CD40之间的相互作用。 CD40抗体对T细胞抗原,哥白尼引起的关节炎和皮肤同种异体体液免疫反应模块有效,并具有抗炎特性。这些化学抗体包括:(a)由全部或部分合成氨基酸序列的AC生物电离层组成的轻链,显示于ID NS1(图4a).O(b)显示为ID ns:2(图4b)。 4b),由全部或部分氨基酸序列的生物活性成分组成的重链; o(c)ambas(a)y(b)Adem sse revelan las mol culas que codifican las cadenas largas ligeras y pesadas de los anticuerpos quis ricos los vectores de exprecrements losanticuerpos humanizados y las composicionesfarmac uticas que contienen dicho s anticuerpos y quim

著录项

  • 公开/公告号AR018101A1

    专利类型

  • 公开/公告日2001-10-31

    原文格式PDF

  • 申请/专利权人 BRISTOL-MYERS SQUIBB COMPANY;

    申请/专利号AR1999P100704

  • 发明设计人

    申请日1999-02-23

  • 分类号C07K16/18;C07K16/46;C12N15/13;C12N15/63;A61K39/395;

  • 国家 AR

  • 入库时间 2022-08-22 01:26:18

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