Methods and compositions for increasing white blood cell count

摘要

Invention Patent: "METHODS AND COMPOSITIONS TO INCREASE WHITE BLOOD CELL COUNT". Methods are shown to raise white blood cell counts in animal subjects using compounds of formula (1). These compounds have the formula: Z-linker-Z '(1) or its pharmaceutically acceptable salt in which Z is a cyclic polyamine containing 9 to 32 ring elements of which 3 to 8 are nitrogen atoms; said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms in addition to nitrogen and / or may be fused to an additional ring system; Z 'can be incorporated in a form as defined by Z above, or alternatively it can be of the formula where each R is independently H or straight, branched or cyclic (1-6C) alkyl, n is 1 or 2, and X is a aromatic ring, including heteroaromatic rings, or is a mercaptan; "linker" represents a bond, alkylene (1-6C) or can comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or can contain keto groups or nitrogen or sulfur atoms; in an amount effective to raise said WBC count in said individual.