Process for the preparation of granular compositions containing macrolu00ecdeos of erythromycin and process for preparation of pharmaceutical compositions containing said macrolu00ecdeos.

摘要

Process for the preparation of granular compositions containing macrolideos of erythromycin and process for preparation of pharmaceutical compositions containing said macrolideos "it is a process ofPreparation of granular compositions containing macrolu00eddios of erythromycin, useful for preparing pharmaceutical formulations which can be administered orally.Of organoleptic characteristics acceptable flavor and aroma - said process including: mixing a resin protonizada particles with a macrolu00eddio of erythromycin in a solvent for said CoMposto, during a time interval sufficient to neutralize and fixed through an acid / base exchange.The macrolu00eddio in granules of resin; grinding the granules of resin treated that way, and, if necessary,With the prior removal of the solvent; classify and select the particles with a predetermined measure of grain and coat the particles classified.Aroma and flavour of substantially neutral, with a biodegradable coating release scheduled macrolu00eddio from resin particles.