The preparation process of nanocu00e1psulas, colloidal suspension and composition of nanocu00e1psulas therapy

摘要

b "preparation process of nanocu00e1psulas,Colloidal suspension of nanocu00e1psulas and therapeutic composition " d this invention deals with the preparation of nanoparticles for the encapsulation of active ingredients.One of the principles of the present invention is to provide a process for obtaining nanocu00e1psulas dispersible in the aqueous phase in vesicular colloidal form, non - toxic bio compatible.Stable colloidal suspension, which protect the active principle and that can be obtained in a simple and economic.The process consists of two stages involve non oily s ~ 1 ~ (ethyl acetate) and S ~ 2 ~ (water),Not miscible between itself and a third oil phase s ~ 3 ~ (migliol); performing an emulsion oil in water phase dispersed which comprises s ~ 3 ~ s ~ 1 ~,Or a polymer b SP d dissolved in S ~ 1 ~ and for forming the shell of the nanocu00e1psulas and possibly an active principle b PA d dissolved (and S ~ 1 ~ is brought by a solution saturadThe S ~ 2 ~ s ~ 1 ~) and whose continuous phase is s ~ 2 ~ = non solvent of PE; and extracting s ~ 1 ~ of dispersed phase.Acting in a way that the conditions of the continuous phase are such that s ~ 1 ~ is miscible in S ~ 2 ~. We obtain a stable colloidal solution of nanocu00e1psulas diameter on the order of 300 nm.