Use of a benzofuroxan series compound, pharmaceutical composition, and processes for the preparation of a parenteral formulation and for the treatment of a mammal, including a human, of coronary heart disease

摘要

"USE OF A COMPOUND FROM THE BENZOFUROXAN SERIES, PHARMACEUTICAL COMPOSITION, AND, PROCESSES FOR THE PREPARATION OF A PARENTERAL FORMULATION AND FOR THE TREATMENT OF A MAMMALIAN, INCLUDING A HUMAN BEING, WITH HEART DISEASES OF THE CORONARY". The invention discloses the use of a benzofuroxan series compound for the treatment of cardiovascular disorders, represented by the general formula (I) and its pharmaceutically acceptable salts, wherein R is halogen, acetoxy, -X-R ', -C (O ) NR "R '' 'or -C (O) C1, where X is oxygen, sulfur, -C (O) -, or -C (O) O-; R' is hydrogen, lower alkyl (C ~ 1 ~ -C ~ 8 ~) straight or branched chain; R "and R '' 'is independently hydrogen, lower alkyl (C ~ 1 ~ -C ~ 8 ~) straight or branched chain or R" and R' '' are linked together with or without heteroatoms such as oxygen or nitrogen in which the substitution in nitrogen is hydrogen or lower alkyl The invention further discloses pharmaceutical compositions containing the compounds of the general formula (I) as active ingredients. process of treating a mammal, including a human, for coronary heart disease by administering an effective amount of a formula (I) as defined above.