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Multivalent immunogenic composition, and, process to stimulate the immune system to produce an immunogenic response to the human rotavirus serotype antigen vp7 without low-level transient fever
Multivalent immunogenic composition, and, process to stimulate the immune system to produce an immunogenic response to the human rotavirus serotype antigen vp7 without low-level transient fever
"MULTIVALENT IMMUNOGENIC COMPOSITION, AND, PROCESS TO STIMULATE THE IMMUNE SYSTEM TO PRODUCE AN IMMUNOGENIC RESPONSE TO THE HUMAN ROTAVIRUS VP7 SERUM TYPE ANTIGEN WITHOUT TRANSIENT LOW SIGNIFICANT LEVEL". The present invention provides vaccine compositions for protection against human rotaviral disease, without significant reactogenicity. Human x bovine reclassifying rotaviruses, comprising each of the four most clinically important VP7 serotypes of human rotavirus, are combined in a multivalent formulation that provides a high degree of infectivity and immunogenicity without producing a transient febrile condition. Processes for producing an immunogenic response without producing a transient febrile condition are also provided.
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