Antigenic composition, method for increasing the capacity of an antigenic composition that contains an antigen selected from a pathogenic bacterium, virus, fungus or parasite, haemophilus influenzae, helicobacter pylori, respiratory syncytial virus, rotavirus, and simple virus of the herpes to evoke the immune response of a vertebrate host, plasmid, host cell, method to produce an immunogenic mutant cholera holotoxin, and use of an effective auxiliary amount of a mutant cholera holotoxin

摘要

"ANTIGENIC COMPOSITION, METHOD FOR INCREASING THE CAPACITY OF AN ANTIGENIC COMPOSITION CONTAINING AN ANTIGEN SELECTED FROM A BACTERIA, VIRUS, FUNGUS OR PATHOGENIC PARASITE TO EVOKE THE IMMUNE RESPONSE OF A HOSPITAL, VERY LARGE HOSPITAL IMMUNOGENIC MUTANT, AND USE OF AN EFFECTIVE AUXILIARY AMOUNT OF A MUTANT CHOLERA HOLOTOXIN "A mutant cholera holotoxin that features a point mutation at amino acid 29 of subunit A, in which the glutamic acid residue is replaced by an amino acid other than no aspartic acid is usable as an adjuvant in an antigenic composition to enhance the immune response in a vertebrate host to an antigen selected from a pathogenic bacterium, virus, fungus or parasite. In a particular embodiment, amino acid 29 is histidine. The mutant cholera holotoxin may contain at least one additional mutation in subunit A at a position other than that of amino acid 29. The antigenic composition may include a second adjuvant in addition to the mutant cholera holotoxin.