Method of production of an injectable formulation in vivo of 3He hiperpolarizado, preparation and subsequent injection of gaseous 3He polarized in vivo, and.Solubilization of 129Xe gas hiperpolarizado, and hiperpolarizado fluid injectable pharmaceutical product in vivo.

摘要

Method of production of an injectable formulation in vivo ^ 3 ^ he hiperpolarizado, preparation and subsequent injection of ^ 3 ^ He gas polarized in vivo, and.Solubilization of ^ 129 ^ Xe gas hiperpolarizado, and.The product hiperpolarizado pharmaceutical injectable fluid in vivo processes to the increase of T ~ 1 ~ formulations of injectable microbubble ^ 3 ^ he hiperpolarizado includes the step of introducing the^ 3 ^ he hiperpolarizado in a quantity of microbubbles retained within a chamber and increasing the pressure inside of the same to facilitate the movement or the loading of the ^ 3 ^ he inside of the ICMRobolhas.Subsqu00b3entemente, a limited quantity of a liquid carrier or a liquid solution carrier alone or pre mixed with ^ 3 ^ *,Can be introduced in the microbolha / ^ 3 ^ he within the chamber to inhibit the tendency of the ^ 3 ^ he leak out of the bubble.Pharmaceutical products related and associated containers as well as a process based on the evacuation to the rapid mixing and distribution of bubbles and ^ 3 ^ * are also described.An additional process for dissolution of gas ^ 129 ^ Xe through the use of bubbles as an accelerator agent is also described.