Derived from beta-starch or beta-sulfonamido carboxylic acids, use of it, pharmaceutical preparation for oral, parenteral and intraperitoneal administration, compound, use of this, and structure fragment

摘要

"DERIVED FROM BETA-STARCH OR BETA-SULPHONAMIDE CARBOXYLIC ACIDS, USE OF THE SAME, PHARMACEUTICAL PREPARATION FOR ORAL, PARENTAL AND INTRAPERITONEAL ADMINISTRATION, COMPOUND, USE OF THIS, AND, STRUCTURAL FRAGMENT". The invention relates to carboxylic acid derivatives of formula (I): in which the substituents have the following meanings: R¹ is tetrazole or a group (a); W and Z, can be identical or different and are nitrogen or methyl, provided that, if W and Z are methyl, then Q is nitrogen; X is nitrogen or CR ^ 9 ^; Y is nitrogen or CR ^ 10 ^; Q is nitrogen or CR ^ 11 ^, provided that if Q is nitrogen then X is CR ^ 5 ^ and Y is CR ^ 10 ^; R² and R³ are identical or different and are possibly substituted phenyl or naphthyl or phenyl or naphthyl that are linked in an ortho position by a direct bond, a methylene, ethylene or ethylene group, an oxygen or sulfur atom or an SO group ~ 2 ~ -, NH- or N-alkyl or possibly substituted C ~ 5 ~ -C ~ 6 ~ cycloalkyl; R ^ 4 ^ is a remainder of (b) or (c); and R5 is hydrogen, C ~ 1 ~ -C ~ 4 ~ alkyl. The invention further concerns its preparation and its use as endothelin receptor antagonists. The invention also concerns compounds of formula (II) and a structural fragment of formula (d) in which the remains of R¹, R², R³, R ^ 4 ^ and R ^ 5 ^ have the meanings given in claim no. 1 and its use as structural elements in an endothelin receptor antagonist.