Method for preparing ferrous gluconate Effervescent Granules) is to mix the components using air at 70 degrees Celsius and the humidity amp; 10 g / kg (b) moisten the Mixture with water mist and evaporate to 35 degrees Celsius (d) repeat these steps until the desired granulated form) and Air Drying to obtain up to 80 degrees Celsius.

摘要

Method for preparing a granule comprising, as active ingredient and pharmacologically, Ferrous gluconate, as Effervescent System, Citric Acid and sodium bicarbonateBy Wet granulation in a fluidized bed Granulator, Said method comprising the steps of (i) to introduce a mixture comprising ferrous gluconate.Citric Acid and sodium bicarbonate in the Granulator, while FED with Air Flow to approximately 70 degrees C.And has a humedda 1.0 g / kg; (ii) to moisten the mixture through water mist when it has reached a temperature of 35 degrees C.Approximately; (iii) evaporate agau foggingKeeping the temperature of the mixture is substantially Constant 35 degrees C; (iv) repeat the phases II and III until it has formed a Granulate which has the characteristics.And have the desired characteristics; and (V) Drying Said Granules with air heated to around 80 degrees C. until its Moisture content is below 0.5% in weight.Granulate thus obtained and Tablets that contain it.