Preparation method of 2 - phenyl - 3 - aminopiridina phenyl substituted Derivatives, and their salts, comprising reacting Pyridine Derivatives with a base and a palladium catalyst.Useful for preparing antagonists of Substance P.

摘要

A procedure for preparing 2 - phenyl - 3 - aminopiridina, phenyl substituted derivatives and salts of these Compounds, in which a compound of formula III or VIIIIs reacted with a compound of formula IV, The reaction in an Inert Solvent, in the presence of a palladium catalyst and a base, to obtain a compound of Formula V or XPreferably, The Compound of formula III and VII is prepared by the reaction of a compound of formula I, a compound of formula I, II, VII, in an Inert Solvent to the reaction.