Polymorphs of diphosphate (2R, 3S, 4R, 5R, 8R, 10R, 11R, 12S, 13S, 14R) - 5 - 2 - didesoxi - 3 - methyl - 3 - methyl - 4 - (propilamino) methyl - alpha - L - ribo - hexopiranosil 2 - ethyl oxy - - - - 3,4,10 trihidroxi 3,5,8,10,12,14 - hexamethyl - 11 - 3,4,6 tridesoxi - - 3 - (dimethylamino) - beta-d - 1oxa xilo hexopiranosil - - 6 - - 15 - azaciclopentadecan Ona and their use in the treatment of Infections bacter....

摘要

Diphosphate Crystalline Salt of (2R, 3S, 4R, 5R, 8R, 10R, 11R, 12S, 13S, 14R) - 13 - (2,6 - didesoxi - 3 - methyl - 3 - methyl - 4 - ((propilamino) methyl) - L - ribo - hexopiranosil) oxy) - 2 - ethyl - 3.4,10 - - - - trihidroxi use hexamethyl - 11 - (3,4,6 - tridesoxi - 3 - (dimethylamino) - B - D - hexopiranosil Oxil xilo)) - 1 - 6 - 15 - azaciclopentadecan oxa - Pharmaceuticals - One; compositions containing the Free Base of diphosphate Salt and its use for the treatment ofBacterial and protozoal infections in mammals and administered parenterally.The preparation method consists in Dissolving the Free Base with Magnetic stirring in absolute ethanol at room temperature; add a Phosphoric Acid solution in absolute ethanol.Over a period of 2 to 3 minutes; The resulting Solid dissolve in water; the Crop Crystalline at room temperature and washed with small portions of a mixture of 10 / 1 (V / V) ethanol and Water.