Acetilcolinestarasa inhibitors in combination with Muscarinic ago nutritionists for the treatment of Alzheimer's disease

摘要

A composition comprising an effective amount of acetilcolesterasa uninhibidor combined with an effective amount of a Muscarinic agonist.A combination of claim 1 wherein the inhibitor of acetylcholinesterase is 1,2,3,4 - tetrahydro - 5 - aminoacridine (tacrine): 1 - Benzyl - (4 - 5.Dimetioxi - 1 - 6 - 2 - indanon) - yl) methyl piperidine (Donepezil); (S) - [N - ethyl - 3 - [(1 - dimethylamino) ethyl] - N - methyl phenyl carbamate (Exelon); OR]), or Dimethyl (2 - hydroxy - 2.2 - tricloroetil) phosphonate (Metrifonate) or benzazepinoles (galantamine).A combination of claim 2, where the Muscarinic agonist is 1,2,5,6 hydrochloride - tetrahydro - 1 - methyl - 3 - pyridine - carboxaldehi do o-methyloxime (milameline): 3 - (Hexyloxy - 1.2.5 - tiodiazol - 4-yl) - 1,2,5,6 - tetrahydro - (1 - metilpi - Ridina xanomeline); 1 - aza Bicyclo [2.2.1] heptan-3-one - O - [3 - (3-methoxyphenyl) - prop - 2 - inil oxime] (CI - 1017), (2R) - 3 - (2 - (2-propynyloxy) quiniclidina talsaclidine Monohydrate); (S) - (-) - 3 - -2.8-dimetil methylene - 1 - oxa - 1 - 8 - [4 - azaspirona.5] Dean L - tartrate (YM - 796) or R (Z) - methoxy imino) - 1 - azobiciclo [2.2.2] octane - 3 - acetonitrile (memric).