The Compound (2S, 3S, 5S) - 2 - (2 - hydroxy - 3 - dimetilfenoxiacetil amino) - 5 - (1 - 2S - tetrahydro - pyrimid - 2 - 3 - metilbutanoil Onil) - amino - 1.6 - difenilhexano,Process for their Preparation and Pharmaceutical formulations containing them

摘要

The compound (2S, 3S, 5S) -2- (2,6-dimethyl-phenoxyacetyl) amino-3-hydroxy-5- [2S- (1-tetrahydro-pyrimid-2- onyl) -3-methylbutanoyl] amino- 1,6-diphenyl-hexane; or a pharmaceutically acceptable drug ester or drug precursor thereof.2 A process for the preparation of the compound of Claim 1, wherein the process comprises: a) reaction of (2S, 3S, 5S) -2-N, N -dibenzylamino-3-hydroxy-5-amino-1,6-diphenylhexane with 2S- (1-tetrahydro-pyrimid-2-onyl) -3-methyl butanoic acid or with a salt or an ester derivative thereof, to obtain (2S, 3S, 5S) -2-N, N-dibenzylamino-3-hydroxy-5- (2S- (1-tetrahydro-pyrimid-2-onyl) -3-methyl butanoyl) amino-1, 6-diphenylhexane;(b) The product of step a reacts with (2S, 3S, 5S) - 2-amino-3-hydroxi-5 - (2S - (1-tetrahydro-pirimid-2-onil) - 3-metal butanil) amine-1, 6-difenilhexane; and (c) the product of step B reacts with 2, 6-dimethoxy acid, or with the active salt of 2, 6-dimethoxyacetic acid or its active derivative.