Pharmaceutical enteric coated tablet and preparation method

摘要

A pharmaceutical component for shaping an oral coating, including a pearl shaped, granular or granular nucleus and an anesthetic coating of the nucleus, The core comprises an acid emulsion with a content of 70% to 100% by weight, a polymer with a content of 0% to 10% by weight, and a solution with a content of 0% to 10% by weight, It also has a numb coating, including a copolymer of metabolized acids and a plasticizer,The intestinal coating protects the core in a low pH environment of 3 or less, and can release the drug to a pH value of 4.5 or more. The drug composition also includes an anti adhesive with a weight between 0.1% and 4.0%, and is within the pH adjustment range of the substance. The intestinal acid coating can reduce the incompatibility between the drug and the internal nucleic acid, as well as the incompatibility between the anesthetic or delayed release,Therefore, the necessity of two or less protective coatings between the linear acid coating and the core is eliminated, and the adjustment of pH value helps the copolymers to decompose rapidly, thus promoting the release of the substance more quickly.In the gastrointestinal region, the pH is 4.5 or greater. 3. A process for preparing the pharmaceutical composition of the gastrointestinal coating, including (a) preparing a dry mixture, including a drug, an adhesive and a selfless agentAnd a part of the dry mixture is separated; (b) a wet mass (a) of the dry mixture is formed in El Paso;(c) Extrude the humidity substance so as to form a high-power pearl shell and turn it into ashes, and contaminate the humidity with the part of dry substance on the aisle;(d) These pearls are coated with linear and plasticized coating polymers in an aqueous environment; and (E) these coated pearls are mixed with an anti adhesive.