Structure analogs for fibroblast growth factors having a modified heparin binding site

摘要

Structural analogues of fibroblast growth factors have at least one point mutation in a heparin binding site. Typical point mutations are deletions or replacements of basic residues with other residues, e.g., neutral or acidic residues. In some embodiments, the analogues have at least one point mutation in a heparin binding site. Preferred analogues have one or two basic residues replaced by glutamine, and exhibit a binding affinity to cell surface receptors similar or superior to native growth factor, but different heparin binding and biological activity from the native growth factor.