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Nucleoside analogues such as antivirals comprising inhibitors of retroviral reverse transcriptase and the hepatitis B virus (HBV) DNA polymerase
Nucleoside analogues such as antivirals comprising inhibitors of retroviral reverse transcriptase and the hepatitis B virus (HBV) DNA polymerase
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机译:核苷类似物,例如包含逆转录病毒逆转录酶和乙型肝炎病毒(HBV)DNA聚合酶抑制剂的抗病毒药
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摘要
A compound of the formula I CHEM wherein: nuc is the residue of a nucleoside analogue bonded through its single hydroxy group on the cyclic or acyclic saccharide moiety, R1 is hydroxy, amino or carboxy; optionally having esterified/amide bonded thereon a C4-C22 saturated or unsaturated, optionally substituted fatty acid or alcohol, or an aliphatic L-amino acid; R2 is the residue of an aliphatic L-amino acid; L1 is a trifunctional linker group; L2 is absent or a difunctional linker group; and pharmaceutically acceptable salts thereof. IMAGE
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