NEW INLINONA LANDS WITH INHIBITING ACTION WITH RESPECT TO DIFFERENT KINAS AND CYCLIN / CDK - COMPLEXES

摘要

The application describes new, valuable properties substituted indolinones of general formula (I) in which X and R-R have the values indicated in claim 1 of the claims, as well as their isomers and salts. The proposed compounds of general formula (I), in which the R is a hydrogen atom, a CC-alkyl group or a prodrug residue, possess valuable pharmacological properties, first of all they exhibit an inhibitory effect on various kinases, viral cyclin and tyrosine kinase receptors, and the rest of the compounds Formula (I) in which R 2 has values other than a hydrogen atom, a CC-alkyl group and a prodrug residue, are valuable intermediates for preparing the compounds mentioned above the first. The international application was published along with an international search report.