MONOCLONAL ANTIBODY ANTI ALPHAV-INTEGRIN AND ITS USE TO INHIBIT ALPHAVBETHA6-INTEGRIN ATTACHMENT TO FIBNRONECTIN

摘要

A monoclonal antibody that: - reacts only with the αv chain of human αv integrins - selectively prevents cells carrying αv 6 integrin from binding to fibronectin as an integrin substrate. The invention further relates to an antibody-producing hybridoma cell line, an antibody-containing pharmaceutical composition and a method for producing the monoclonal antibody. The present invention relates to the use of an antibody according to the invention for the production of an agent which is antitumor of tumor, preferably colon or lung cancer cells, or for the diagnostic locating and evaluation of tumor growth. SHE