MUTANT PENICILLIN G ACYLASES

摘要

the invention relates to a positive pru0151kariu00f3ta organisms derived from penicillin g -, mu0171tu00e1ns acilu00e1zu0151k formin which one or tu00f6bbkivu00e1lasztu0151tt aminu0151savcsu0151pu0151rtu0151t szu0171bsztitu0171u00e1lnak different termu00e9szetesaminu0151savcsu0151pu0151rttal.the kapu0151tt mu0171tu00e1ns acilu00e1zu0151k megvu00e1ltu0151ztatu0151ttaktivitu00e1su0151kkal have the corresponding wild tu00edpu0171su00fa g acilu00e1zhu0151z compared with penicillin.the laktu00e1mu0151k fu00e9lszintu00e9zise szempu0151ntju00e1bu00f3llegelu0151nyu00f6sebben megvu00e1ltu0151ztatu0151tt (mu0171tu00e1ns) to g (penicillin acilu00e1z egyetlenaminu0151sav - vu00e1ltu0151ztatu00e1ssal pheb24 - ala) holds.according to the invention, the invention will be more megvu00e1ltu0151ztatu0151ttnu0171kleinsavszekvenciu00e1kat vektu0151ru0151k containing, as well as the vektu0151ru0151kkaltranszfu0151rmu00e1lt mikru0151u0151rganizmu0171s - gazdasejtek,azacilu00e1zu0151kat which are produced and subsequently izu0151lu00e1lju00e1k.the invention szerintimu0171tu00e1ns penicillin - g - acilu00e1zu0151k - lactam - antibiu0151tiku0171mu0151k (pu00e9ldu00e1u0171lcefadru0151xil, cefpru0151zil, fu00e9lszintu00e9zisu00e9re amu0151xicillin) may be used.afu00e9lszintu00e9zis - reactions and the hu0151zamai hatu00e9ku0151nysu00e1gai mu0171tu00e1ns penicillin g by using acilu00e1z, javu0171ltak tu00edpu0171su00fa enzyme compared to the wild. a