PEPTIDES AND ANALOGUES AND MIXTURES THEREOF FOR DETECTING AND ELICITING ANTIBODIES TO THE E1 AND E2 PROTEIN OF RUBELLA VIRUS

摘要

A peptide of the formula: a--Y--b, wherein: Y is a sequence of at least six amino acids taken as a block from the amino acid sequence of the E2 glycoprotein of a strain of rubella virus that corresponds to AA11-AA37 of the E2 glycoprotein of the Therien strain of rubella virus, in which block the sequence extends in the N terminus to C terminus direction of the native amino acid sequence, 3 ט" ז בטבת התשס" א - January 11, 2001 a is selected from the group consisting of: (i) an amino terminus; (ii) a sequence of one to eight amino acids; (iii) a substituent effective to facilitate coupling, and (iv) a substituent effective to improve the immunogenic or antigenic activity of the peptide; and b is selected from the group consisting of: (i) a carboxy terminus; (ii) a sequence of one to eight amino acids; (iii) a substituent effective to facilitate coupling; and (iv) a substituent effective to improve the immunogenic or antigenic activity of the peptide.