2,3-DIOXO-1,2,3,4- TETRAHYDRO- QUINOXALINYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Anti-convulsive 2,3-dioxo-1,2,3,4- tetrahydro-quinoxalinyl derivatives of the formula wherein one of the radicals R1 and R2 is hydrogen and the other is a group of formula -alk-N(R8)-X- R7, -alk-O-X-R7 or -alk-S-X-R7, one of the radicals R3 and R4 is hydrogen, halogen or nitro and the other is halogen or nitro, R7 is carboxy, lower alkoxycarbonyl; phenyl-lower alkoxycarbonyl that is unsubstituted or substituted by lower alkyl, lower alkoxy, hydroxy, halogen and/or by trifluoromethyl; carbamoyl; phenylcarbamoyl that is unsubstituted or substituted by lower alkyl, lower alkoxy, hydroxy, halogen, nitro, carboxy, lower alkoxycarbonyl, phenyl, phenyloxy and/or by trifluoromethyl; phosphono, mono- di- or tri-lower alkylphosphono or tetrazolyl, R8 is hydrogen, lower alkyl or, together with X and the nitrogen atom bonding R8 and X forms a pyrrolidinylene, piperidinylene or piperazinylene radical, alk is lower alkylene, and X (unless, המדפיס הממשלתי מכשיר שרת, יומן הפטנטים, עמ' together with R7 and R8 and the nitrogen atom bonding R8 and X, it forms part of one of the mentioned ring systems) is a direct bond, C1-C7 alkylene, C1-C4 alkylidene, oxo-C1-C4 alkylene including carbonyl, oxo-C1-C4 alkenylene, amino-C1-C4 alkylidene, oxo-C1-C4 alkylene including carbonyl, oxo-C1-C4 alkenylene, amino-C1-C4 alkylidene, carboxy-C1-C4 alkylidene, C1-C4-alkoxycarbonyl-C1-C4 alkylidene, g-aza-a oxo-C1-C4alkylene or g-aza-a oxo-C1-C4 alkenylene, or unsubstituted or halo- and/or trifluoromethyl-substituted phenyl-C1-C4 alkylidene, or salts thereof. _______________