Oral delayed immediate release formulation comprising a compressed core with a coating for immediate release of an active substance after a definite time period

摘要

An oral delayed immediate release formulation comprises a compressed core containing one or more active substances surrounded with a coating. The release of the active substance from the core is caused by rupture of the coating after a definite lag-time. The core comprises one or more immediate release carriers and having no substantial swelling properties upon exposure to gastrointestinal fluids. Also disclosed are formulations containing an oral immediate release formulation combined with one or more oral delayed immediate release formulations with different lag-times. The oral delayed immediate release formulation may be used for the application of active substances such as anti-asthmatics, anti-emetics, cardiotonics, vasodilators, anti-vertigo and anti-ménière compounds, anti-hypertensives, sedatives, anti-depressants, anti-anxiety compounds, corticosteroids, anti-inflammatory compounds, anti-ulceratives, analgetics, anti-arrhythmics, anti-rheumatics, anti-arthritic compounds and anti-angina compounds. The oral delayed immediate release formulation may also be used for the application of biological active compounds such as proteins, peptides, enzymes, vaccines and oligonucleotides.