首页>
外国专利>
Adenoviruses having altered hexon proteins which present epitopes that are not recognised by neutralizing antibodies to the unmodified adenovirus of another serotype
Adenoviruses having altered hexon proteins which present epitopes that are not recognised by neutralizing antibodies to the unmodified adenovirus of another serotype
Described are adenoviruses in which a portion of the hexon protein is changed and preferably, wherein at least a portion of at least one of the L1 and L2 and/or L4 loop regions of the hexon of the adenovirus of a first serotype is removed and replaced with at least a portion of one of the L1 and L2 loop regions of the hexon of a second serotype of at least
展开▼