ADENOVIRUSES HAVING ALTERED HEXON PROTEINS

摘要

An adenovirus wherein at least one portion of at least one loop region of thehexon is changed. In one embodiment, the adenovirus, prior to modification, isof a first serotype, and at least a portion of at least one loop region of thehexon is removed and replaced with at least a portion of at least one loopregion of the hexon of an adenovirus of a second serotype. Such modifiedadenoviruses do not have epitopes which are recognized by neutralizingantibodies to the unmodified adenovirus of the first serotype.