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Method for preparing and purifying an N-alkylated aspartame derivative (neotame) useful as a sweetening agent
Method for preparing and purifying an N-alkylated aspartame derivative (neotame) useful as a sweetening agent
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机译:制备和纯化用作甜味剂的N-烷基化的阿斯巴甜衍生物(neotame)的方法
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摘要
A method for preparing and purifying N-[N-(3,3-dimethylbutyl)-L- alpha -aspartyl]-L-phenylalanine 1-methyl ester from aspartame (of the formula shown) and 3,3-dimethylbutyraldehyde by hydrogenation in an organic solvent solution followed by the formation of an aqueous/organic solvent solution having an organic solvent content of about 17% to about 30% by weight of the aqueous/organic solvent solution.
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