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Pharmaceutical composition of an active compound in an ionic polymer increasing bioavailability of poorly soluble complexes
Pharmaceutical composition of an active compound in an ionic polymer increasing bioavailability of poorly soluble complexes
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机译:离子聚合物中活性化合物的药物成分,可提高难溶性复合物的生物利用度
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摘要
Stable water-insoluble complexes of poorly soluble compounds molecularly dispersed in water-insoluble ionic polymers are disclosed. Useful insoluble ionic polymers have a molecular weight greater than about 80,000 D and a glass transition temperature equal to or greater than about 50 DEG . The compounds are microprecipitated in the ionic polymers in amorphous form. The complexes according to the present invention significantly increase the bioavailability of poorly soluble therapeutically active compounds.
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