AN INSIGHT INTO HOW CYCLODEXTRINS INCREASE THE OCULAR BIOAVAILABILITY OF POORLY WATER-SOLUBLE COMPOUNDS

机译：环糊精如何提高水溶性较差化合物的生物利用度

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The mechanism by which hydroxypropyl-β-cyclodextrin (HP-β-CD) influences the ocular bioavailability of topically administered poorly water-soluble steroids has been investigated using in vitro experimental and theoretical techniques. The aqueous diffusion of the steroid-cyclodextrin inclusion complex has a significant influence on the net flux of steroid through the absorbing membrane.

机译：羟丙基-β-环糊精（HP-β-CD）影响局部施用较差的水溶性类固醇的眼生生物利用度的机理已经采用体外实验和理论技术研究。类固醇 - 环糊精包合物的水性扩散对通过吸收膜的类固醇的净助焊剂产生显着影响。

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《International symposium on controlled release of bioactive materials;Consumer diversified products conference》|2001年|p.253-254|共2页
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A.R. Bary; I. G. Tucker; N.M. Davies;
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中图分类基础医学;
关键词
ophthalmic delivery; cyclodextrins; diffusion;

机译：眼科给药;环糊精扩散;

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1. Effect of liquid crystals with cyclodextrin on the bioavailability of a poorly water-soluble compound, diosgenin, after its oral administration to rats [J] . OkawaraM., HashimotoF., TodoH., International Journal of Pharmaceutics . 2014,第1a2期

机译：含环糊精的液晶对水溶性差的化合物薯os皂苷元口服后对大鼠生物利用度的影响
2. Increasing bioavailability of very poorly water-soluble compounds. A case study of an anti-tumor drug, soloxolon methyl [J] . Ogienko A. G., Markov A. V, Senkova A. V, Journal of drug delivery science and technology . 2019,第期

机译：增加水溶性化合物非常差的生物利用度。抗肿瘤药物，Soloxolon甲基的案例研究
3. Water-soluble beta-cyclodextrins in paediatric oral solutions of spironolactone: preclinical evaluation of spironolactone bioavailability from solutions of beta-cyclodextrin derivatives in rats. [J] . Kaukonen AM, Lennernas H, Mannermaa JP Journal of Pharmacy and Pharmacology . 1998,第6期

机译：螺旋酮小儿口服溶液中的水溶性β-环糊精：从β-环糊精衍生物溶液中的螺旋体生物利用度的临床前评价。
4. Improvement of Bioavailability of Poorly Water-Soluble Drugs :Prediction of Theoretical Intrinsic Bioavailability [C] . Woo Sik Choi, Min Jae Sung, Bong June Cha, 40th Annual Loss Prevention Symposium . 2006

机译：水溶性差的药物的生物利用度的提高：理论固有生物利用度的预测
5. Development of bioadhesive formulations to increase the bioavailability of ocular drugs. [D] . Ceulemans, Jens Jozef. 2002

机译：开发生物粘附制剂以增加眼科药物的生物利用度。
6. Phosphated cyclodextrins as water-soluble chiral NMR solvating agents for cationic compounds [O] . Cira Mollings Puentes, Thomas J Wenzel 2017

机译：磷酸化环糊精作为阳离子化合物的水溶性手性NMR溶剂
7. Effect of liquid crystals with cyclodextrin on the bioavailability of a poorly water-soluble compound, diosgenin, after its oral administration to rats [O] . Masaki Okawara, Fumie Hashimoto, Hiroaki Todo, 2014

机译：液晶与环糊精对水溶性化合物，稻蛋白的生物利用度，其口服给予大鼠

AN INSIGHT INTO HOW CYCLODEXTRINS INCREASE THE OCULAR BIOAVAILABILITY OF POORLY WATER-SOLUBLE COMPOUNDS

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