Process for making flurbiprofen lozenges by granulating flubiprofen with a bulking agent (selected from calcium carbonate, tricalcium phosphate or microcrystalline cellulose)

摘要

A process producing a pharmaceutical lozenge formulation comprising the steps of: 1).granulating a mixture of flurbiprofen and a bulking agent selected from calcium carbonate, tricalcium phosphate or microcrystalline cellulose with a solution of a binding agent in a polar solvent to form granules; 2).melting a lozenge-forming composition; 3).mixing the granules with the molten lozenge-forming composition; 4).forming the resulting mixture into lozenges each containing a therapeutically effective amount of flurbiprofen.