Indole and 2,3-dihydroindole derivatives useful for inhibiting serotonin reuptake and antagonism of 5-HT1a receptors

摘要

An indole or 2,3-dihydro-indole derivative of formula (I), its enantiomers or mixtures thereof, or an acid addition salt thereof, wherein: X is -O-, -S-, or -CR4R5-; Y is -CR6R7-, -CR6R7-CR8R9-, or -CR6=CR7-; or X and Y together form a group -CR4=CR5-, or -CR4=CR5-CR6R7-; Z is-O-, or -S-; W is N, C, or CH; A is a group selected from a group of formula (II), (III) and (IV) wherein the dotted lines mean an optional bond; R1, R2, R3, R12, R13, R14, R15, R16 and R17 are each independently selected from hydrogen, halogen, trifluoromethyl, alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, hydroxy, formyl, acyl, amino, alkylamino, dialkylamino, acylamino, alkoxycarbonylamino, aminocarbonylamino, alkylaminocarbonylamino, dialkylaminocarbonylamino, nitro and cyano; R4, R5, R6, R7, R8 and R9 are each independently selected form hydrogen and alkyl; R11 is selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, acyl and formyl. The compounds are useful for the treatment of diseases that respond to serotonin reuptake and antagonism of 5-HT1A receptors.