Binuclear transition metal complex and its use as a photoinduced nucleic acid cleavage agent, or its use for treating cancer, tumours or infections

摘要

The binuclear DNA-threading transition metal complex has the general formula: (L1)-M1-(D1-B-D2)-M2-(L2) wherein: D1-B-D2 is a bridging ligand; D1 is a polycyclic heteroaromatic ligand with at least four rings, in which aza nitrogens can form a bidentate or tridentate chelate with M1; D2, identical with or different from D1, is any bi- or oligodentate ligand co-ordinated to the transition metal M2; B, covalently linking the ring system D1 to D2, is any appropriately substituted chain of at least two atoms; M1 is a transition metal ion with octahedral co-ordination sphere that is capable of forming substitution-inert co-ordination bonds to the D1 moiety of the bridging ligand as well as to at least one of the bi- or polydentate ligands of set L1; M2 is any transition metal ion; L1 comprise a set of 1-3 ancillary ligands that saturate the remaining co-ordination sphere of M1, at least one of these ligands forming substitution-inert co-ordination bonds to M1 in a bi-, tri- or tetradentate chelate; L2 comprises a set of 1-4 ancillary ligands that saturate the remaining co-ordination sphere of M2. Also described are pharmaceutical compositions (especially cytostatic compositions and antibiotics) comprising the complex described above. The complexes described above are used as photo-induced nucleic acid cleavage agents; or used for treating cancer, tumours, or infection.