The use of a combination of tipranavir and ritonavir for improving the pharmacokinetics of tipranavir

摘要

Refers to the use of the combination of (a) [R - (R *, R *)] - N - [3 - [[1 - 56 - dihydro - 4 - hydroxy - 2 - oxo - 6 - (2-phenylethyl) - 6 - propyl - 2H - piran - 3 - il] propyl] phenyl] - 5 - (trifluoromethyl) - 2 - (piridinsulfonamida) 200 mg tipranavir) used to 7500 mg; (b) 30 mg to 1000 mg ((2S, 3S,(5S) - 5 - (N - (N - methyl - N - isopropyl 2 - (4-thiazolyl) methyl) amino) carbonyl) - L - valinil) amino) - 2 - (N - (5 - (2-amino-4-thiazolyl - (Methoxycarbonyl) amino) - Diphenyl - 3 - hidroxihexano) (ritonavir).Also relates to a method for increasing Blood concentrations of tipranavir and ritonavir in a human being.The use of Combination of tipranavir and ritonavir improves the pharmacokinetics of tipranavir can therefore be useful for treating patients infected with the human immunodeficiency virus (VIH)