(+) - 6 - (6 - amino - chlorine - pyridin-3-yl) - (3H) - 3 - methyl imidazole - 4-yl) methyl - 4 - (3 - chloro phenyl) - 1 - ciclopropilmetil - 1H - quinolein - 2 - ona as Anticancer compound and Method separation of Enantiomers of useful PTo synthesize The Compound

摘要

Refers to (+) - 6 - [(6 - amino - chlorine - pyridin-3-yl) - (3H) - 3 - methyl imidazole - 4-yl) methyl] - 4 - (3 - chloro phenyl) - 1 - ciclopropilmetil - 1H - quinolein - 2 - ona.It also relates to a composition comprising as chemotherapeutic agents or inhibitors of metalloprotease inhibitors of MMP9, MMP2; inhibitors of signal transduction.Antiproliferative agents, agents capable of blocking ctl4; a method to separate enantioanmeros (+) and (-) of the compound of formula I of the racemic mixture, where R1 is H,;C1 - C10 alkyl; R2 is Halo, cyano, coor15; R7 R3 - C1 - C10 is H, alkyl, alquenilo C2 C10, among others; Z is Aromatic heterocycle of 4 - 10 members; R9 is - (cr13r14) T (imidazolilo)R9 is (cr13r14) T (pyridinyl); R12 is H, alkyl (C1 - C10, cr13r14) T (cycloalkyl C3 - C10), among others; R13 and R14 is H, alkyl C1 - C10; t is 0 - 5; Q is 1 to 5; R15 is not h, R12; n is 1 - 3.A method for Synthesizing enantiomerically Pure (+), (-).The Compound Inhibits farnesyltransferase and Abnormal cell growth and may be useful in the treatment of Lung Cancer, Bone, pancreas, Skin