NOVEL SYNTHETIC PEPTIDE, LUBGS SURFACTANT CONTAINING SUCH PEPTIDE AND AGENT FOR TREATING RESPIRATORY INSUFFICIENCY SYNDROME

摘要

A synthetic peptide containing the following sequence: Xaa-Pro-Val-Xbb-Xcc-Lys-Arg-W, (wherein Xaa is absent or represents Cys or Ser; Xbb represents His or Asn; Xcc represents Leu or Ile; and W represents a hydrophobic peptide portion); an intermediate for producing the peptide; a process for producing the peptide; a lung surfactant comprising the peptide and a lipid mixture; and a remedy for respiratory distress syndrome containing the surfactant as the active ingredient. The peptide is easy to isolate and purify and suitable for mass production. As it is highly soluble in methanol and the like, it can readily be blended with a lipid mixture and is suited for the preparation of a lung surfactant. As the lung surfactant has a good suspensibility and a potent surface activity, it is useful as a remedy for respiratory distress syndrome.