PEPTIDES CAPABLE TO INHIBIT INTERACTIONS BETWEEN PRESENILINS AND A PRECURSOR OF BETA-AMYLOID PEPTIDE OR BETA-AMYLOID PEPTIDE ITSELF AND METHOD OF SEARCHING FOR SUCH INHIBITING PEPTIDES

摘要

A new polypeptide (I) is able to at least partly inhibit the interaction between a presenilin (PS) and a beta -amyloid peptide ( beta A) and/or its precursor, amyloid precursor protein (APP). Independent claims are also included for the following: (a) compounds (II) that are not exclusively peptides, with the same activity as (I) obtained by reproducing the active motifs of (I); (b) a nucleic acid (III) encoding (I) or (II); (c) a recombinant defective virus or vector containing (III); (d) an expression cassette usable in the vector of (c); (e) a host cell transformed with (III); (f) recombinant production of (I) or (II) by culturing cells of (e); (g) an antibody, or its fragments, directed against peptides (IV; 87 amino acids), (V; 81 amino acids) or fragments of (VI; 695 amino acids) able to inhibit interaction between PS and beta A or APP; (h) methods for identifying or isolating compounds that can inhibit an interaction between PS and beta A or APP; (i) a method for detecting interaction between PS and beta A or APP by fluorescence transfer between two bound fluorophores; and (j) ligands of (I), (II), PS, beta A or APP identified by these methods.