WATERSOLUBLE POWDERS FOR PERORAL SOLUTION AND THEIR USE

摘要

New water-soluble powdery or grainy pharmaceutical forms for the use in the veterinary medicine are described, containing a therapeutically effective quantity of amoxicillin trihydrate and potassium clavulanate combined with a filler acceptable in the veterinary medicine and at least one buffer compound. The latter is suitable to maintain the pH value of a medium between 6,0 and 8,5 under the fast and complete dissolution of the above mentioned pharmaceutical forms in drinking water for animals. After dissolution in water, clear solutions are stable for at least 24 hours. Phosphate buffers, such as monosodium dihydrogen phosphate dihydrate/ sodium hexametaphosphate, are used preferentially, maintaining the pH value of water medium between 6,5 and 7,5, preferably near 7,0. In accordance with the scope of the invention, the occurrence of any solutions known for causing problems in water tanks for cattle is avoided, such as the sedimentation at the bottom of a tank, bringing about technical problems of cloggings in the piping system for the supply of drinking water for animals.