PURIFIED AND ISOLATED POLYNUCLEOTIDE SEQUENCES ENCODING HUMAN PROTOCADHERINS PC3, VECTOR, HOST CELL, HUMAN PROTOCADHERINS PC3, METHODS FOR PRODUCING THEREOF, AND METHODS FOR MODULATING ITS BINDING ACTIVITY, ANTIBODY, CELL LINE

摘要

A purified and isolated polynucleotide sequence encoding human protocadherin pc3 having the amino acid sequence set forth in SEQ ID NO: 110 or a polypeptide analogue thereof in which one or more specified amino acids are deleted or replaced, or one or more non-naturally occurring amino acids are added without losing one or more biological activities or immunological characteristics specific to the protocadherin pc3 or bypassing the specific ligand / antiligand binding function of the protocadherin pc3, the protocadherin, a biologically functional DNA vector containing a defined DNA sequence, a vector in which said DNA sequence is operably linked to a DNA sequence regulating expression, a host cell transformed or transfected with said DNA sequence in a manner allowing said host cell to express a protocadherin polypeptide, a method of producing said a peptide thereof, an antibody substance specific for human protocadherin pc3, in particular a monoclonal antibody; a hybridoma cell line producing a monoclonal antibody and a method of modulating the binding activity of human protokaderin pc3.à