BIFUNCTIONAL DERIVATIVES OF UROKINASE WITH IMPROVED FIBRINOLYTIC ACTIVITY AND THROMBIN INHIBITING ACTIVITY

摘要

The present invention relates to bifunctional variants of urokinase with improved fibrinolytic properties and thrombin-inhibiting effect, plasmids used in obtaining these polypeptides, as well as thrombolytics which contain bifunctional variants of urokinase as active ingredient.