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Method for selective methionine starvation of malignant cells in mammals
Method for selective methionine starvation of malignant cells in mammals
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机译:哺乳动物恶性细胞选择性蛋氨酸饥饿的方法
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摘要
An improved method for chemotherapy of mammalian malignant cells which have an absolute requirement for methionine but lack methylthioadenosine phosphorylase (MTAse). The method comprises detection of MTAse negative cells in a mammal, administration of methionine gamma -lyase in sufficient amounts to reduce the volume of MTAse negative cells in the mammal, and co-administration of methylthioadenosine in amounts sufficient to ensure the continued availability of methionine to the mammal's non-malignant cells. Means for detection of MTAse negative cells are provided. Means for production and use of recombinant chemotherapeutic agents are also provided.
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