Synthetic opioid peptides exert their action acting selectively on Kappa opioid receptor agonist

摘要

The highly selective and long acting peripheral peptides of opium like receptor kappa (Republic of Korea) without obvious brain penetration are generated according to the sequence of D isomers of four amino acids, including C-terminal amino amide monomers or Bi suStituidas. Synthesis of opiamide or a salt acceptable for the same drug is characterized by the affinity of opioid receptor, which is at least 1000 times higher than that of opioid receptor, and has a lasting effect in vivo management.The formula is: h-xa1-xa2-xa3-xa4-q, XA1 is (a) d-phe (calfame), d-phe, d-tyre, d-ict or D-Ala (cyclopentane or Tianjin),One contains a drug resistance, a polychlorophenylmethyl ester, a acaricide, a drug resistance, a polychlorophenylmethyl ester, and A pharmaceutically acceptable liquid or solid transport that is effective in the presence of visceral pain, rheumatoid arthritis, chronic or acute pain, in the management of urinary instability, incontinence or gastrointestinal disorders, or in the fight against IBD or autoimmune diseases.